Outside the brain, FOXP2 has also been implicated in development of other tissues such as the lung and digestive system. Studies of the gene in mice and songbirds indicate that it is necessary for vocal imitation and the related motor learning. In humans, mutations in FOXP2 cause the severe speech and language disorder developmental verbal dyspraxia. FOXP2 is also required for the proper development of speech and language in humans. įOXP2 is found in many vertebrates, where it plays an important role in mimicry in birds (such as birdsong) and echolocation in bats. It is expressed in the brain, heart, lungs and digestive system. FOXP2 is a member of the forkhead box family of transcription factors, proteins that regulate gene expression by binding to DNA. negative regulation of transcription, DNA-templatedįorkhead box protein P2 ( FOXP2) is a protein that, in humans, is encoded by the FOXP2 gene.positive regulation of mesenchymal cell proliferation.negative regulation of transcription by RNA polymerase II.positive regulation of epithelial cell proliferation.regulation of transcription, DNA-templated. ![]() positive regulation of epithelial cell proliferation involved in lung morphogenesis.
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